2014-03-10 ·
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The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009] 9GAG is on Facebook. To connect with 9GAG, join Facebook today.
By far, most of the research on miRNA and human pathology has focused on examining the role of the miRNA genes themselves in the disease process, with many studies using high throughput methods to analyze global miRNA expression in clinical samples, but reveals little about the underlying miRNA expression problem that promotes the disease process.
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miR-9 is one of the most highly expressed miRNAs in the vertebrate brain. Since its first appearance in the bilaterian line (Wheeler et al., 2009), miR-9 activity shows high versatility, exerting different and often opposite functions in a species- and cellular-specific context, while maintaining high sequence conservation. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.
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Unlike other available miRNA expression vectors, the miRNA precursor is cloned into the intron of human housekeeping gene EF1a promoter region. start codons within the pri-miRNA.